Clinical Test Expectation – GLP-1 – Human Subjects : Lower blood sugar levels, enhance insulin secretion, improve heart, liver, and lung function while helping to slow or prevent the effects of Alzheimer’s disease. Decrease appetite by delaying gastric emptying and reducing intestinal motility. Reduce weight gain
Strength – 3MG per vial
Along with helping to control blood sugar and boost weight loss, GLP-1s and SGLT-2 inhibitors seem to have other major benefits. Research has found that some drugs in these groups may lower the risk of heart disease, such as heart failure, stroke and kidney disease.
There’s a class of type 2 diabetes drugs that not only improves blood sugar control but is best for weight loss. This class of drugs is commonly called glucagon-like peptide 1 (GLP-1) agonists (semaglutide). A second class of drugs that may lead to weight loss and improved blood sugar control is the sodium glucose cotransporter 2 (SGLT-2) inhibitors. These include canagliflozin (Invokana), ertugliflozin (Steglatro), dapagliflozin (Farxiga) and empagliflozin (Jardiance).
Weight loss can vary depending on which GLP-1 drug you use and your dose. Studies have found that all GLP-1 drugs can lead to weight loss of about 4.8 to 7.2 kilograms, when using liraglutide. Studies found people using semaglutide and making lifestyle changes lost about 15.3 kilograms versus 2.6 kilograms in those who didn’t use the drug.
Diabetes drugs in the GLP-1 agonists class are generally taken by a shot (injection) given daily or weekly and include:
- Dulaglutide (Trulicity) (weekly)
- Exenatide extended release (Bydureon bcise) (weekly)
- Exenatide (Byetta) (twice daily)
- Semaglutide (GLP-1/Ozempic) (weekly)
- Liraglutide (Victoza, Saxenda) (daily)
- Lixisenatide (Adlyxin) (daily)
- Semaglutide (Rybelsus) (taken by mouth once daily)
These drugs mimic the action of a hormone called glucagon-like peptide 1. When blood sugar levels start to rise after someone eats, these drugs stimulate the body to produce more insulin. The extra insulin helps lower blood sugar levels.
Lower blood sugar levels are helpful for controlling type 2 diabetes. But it’s not clear how the GLP-1 drugs lead to weight loss. Doctors do know that GLP-1s appear to help curb hunger. These drugs also slow the movement of food from the stomach into the small intestine. As a result, you may feel full faster and longer, so you eat less.
Along with helping to control blood sugar and boost weight loss, GLP-1s and SGLT-2 inhibitors seem to have other major benefits. Research has found that some drugs in these groups may lower the risk of heart disease, such as heart failure, stroke and kidney disease. People taking these drugs have seen their blood pressure and cholesterol levels improve. But it’s not clear whether these benefits are from the drug or the weight loss.
The downside to GLP-1 drugs is that all but one has to be taken by a shot. And, like any drug, there is a risk of side effects, some serious. More common side effects often improve as you continue to take the drug for a while.
Some of the more common side effects include:
Low blood sugar levels (hypoglycemia) are a more serious risk linked to the GLP-1 class of drugs. But the risk of low blood sugar levels often only goes up if you’re also taking another drug known to lower blood sugar at the same time, such as sulfonylureas or insulin.
The GLP-1 class of drugs isn’t recommended if you have a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia. Lab studies have linked these drugs with thyroid tumors in rats. But until more long-term studies are done, the risk to humans isn’t known. They’re also not recommended if you’ve had pancreatitis.
Dosing Details – GLP-1 3MG – Weight loss protocol
You inject 3ml water into the vial of GLP-1 from the water vial. 1 full syringe is 1ml. You then wait for the vial powder content to dissolve ON ITS OWN. DO NOT SHAKE THE VIAL TO MIX POWDER. Once dissolved and clear in colour the vial is ready for use. GLP-1 vials mixed or unmixed, need to be kept in the fridge, not the freezer. They must be stored between 4 and 20 celcius.
START DOSE : The start dose is 0.25 mg once a week for the first 4 weeks. This will help give your body a chance to get used to the medicine.
Week 1 – 4 : 0.25mg per week
You draw out 0.25 (2.5 on syringe – is below the 10 mark) once a week and inject subcutaneously into the stomach. These injections can be taken with or without food. The injection should be taken on the same day each week at more or less the same time, and injected into the tummy under the skin, into the fatty layer. Your first course should use 1mg of the 3 mg vial (one third of the vial).
INTERMEDIARY DOSE : At week 5, your dose should increase to 0.5 mg once a week to maintain results.
Week 5 – 8 : 0.5mg per week
You draw out 0.5 (5.0 on syringe – is below the 10 mark) once a week and inject subcutaneously into the stomach. These injections can be taken with or without food. The injection should be taken on the same day each week at more or less the same time, and injected into the tummy under the skin into the fatty layer. Your intermediary course should use 2mg of the 3 mg vial (two thirds of the vial).
ADVANCED DOSE : At week 9, your dose can increase to 0.75 mg once a week to maintain results and no more than 1mg.
Week 9 – 12 : 0.75mg per week
You draw out 0.75 (7.5 on syringe – is below the 10 mark) once a week and inject subcutaneously into the stomach. These injections can be taken with or without food. The injection should be taken on the same day each week at more or less the same time, and injected into the tummy under the skin into the fatty layer. Your advanced course should use 3mg of the 3 mg vial (entire vial).
You may change the day of the week you use GLP-1 as long as your last dose was taken 2 or more days before.
GLP-1 5MG VIAL OPTION : Additional support for diabetes
Your average blood sugar level needs may shift as your type 2 diabetes changes. That’s why we offer offer higher strength vials that deliver up to 5mg a vial, where for this maintenance of blood sugar levels may require doses of 1 mg or 2 mg per injection, to give you additional average blood sugar control. And while your dose may change, nothing will change about how you take GLP-1 in terms of administration.
USE OF GLP-1 FOR BLOOD SUGAR CONTROL IN DIABETICS, MUST BE DIAGNOSED, PRESCRIBED AND MANAGED BY A QUALIFIED MEDICAL PROFESSIONAL ONLY. RESEARCH PEPTIDES SOUTH AFRICA IS NOT ABLE TO ASSIST WITH THIS AND CANNOT SUPPLY THIS ITEM FOR USE IN THIS WAY WITHOUT VALID DOCTORS SCRIPT AND AUTHORIZATION.
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